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Jingdong book

高原分子医学

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高原分子医学

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《高原分子医学》探讨高原缺氧导致高原反应与疾病的细胞和分子生物学基础改变,为深入研究高原病的发病、诊断、治疗奠定基础,为探索高原病防治的新方法、新技术提供可靠的理论基础和临床研究依据,有利于提高高原地区的卫生保障和卫生防护水平。全书在系统总结西藏民族学院近年来在高原分子医学研究成果的基础上,参阅了大量国内外相关文献,从理论上介绍高原缺氧对人体各组织细胞代谢和功能的影响,内容包括低氧适应相关基因与低氧应激反应、慢性高海拔低氧的细胞感受和分子适应、组织与细胞水平上高原适应机制、心肌低氧适应的信号传导等。
Catalogue

1 绪论
2 高原缺氧对细胞的影响及其分子机制
2.1 高原缺氧对细胞结构、功能代谢的影响及其分子机制
2.1.1 高原缺氧对细胞分子结构的影响
2.1.2 高原缺氧对细胞功能代谢的影响
2.1.3 缺氧性细胞损伤
2.2 高原缺氧时细胞反应的改变及其分子机制
2.2.1 氧感受和氧感受器
2.2.2 不同细胞的氧感受途径
2.2.3 缺氧信号转导通路
2.2.4 缺氧对细胞增殖的影响及其分子机制
2.2.5 缺氧对细胞分化的影响及其分子机制
2.2.6 缺氧与细胞凋亡

3 高原缺氧的神经内分泌调节
3.1 主要神经内分泌器官
3.1.1 下丘脑的组成及其功能
3.1.2 垂体的组成及其功能
3.2 高原缺氧时神经内分泌系统的主要调节机制
3.2.1 下丘脑垂体甲状腺轴
3.2.2 下丘脑垂体肾上腺轴
3.2.3 下丘脑垂体性腺轴
3.3 急慢性高原病的发病机制及其预防
3.3.1 急性高原病
3.3.2 慢性高原病

4 高原缺氧与分子免疫学
4.1 低氧环境对红细胞免疫功能的影响
4.2 低氧环境对免疫细胞功能的影响
4.2.1 低氧环境影响免疫细胞分泌炎症因子及其受体的表达
4.2.2 淋巴细胞膜K(v)通道在低氧免疫及适应中的作用
4.2.3 缺氧环境对免疫细胞分化、凋亡的影响
4.2.4 低氧环境对免疫细胞能量代谢的影响
4.3 高原缺氧的免疫损伤机制
4.4 长期驻不同海拔高原对官兵体液免疫功能的影响
4.5 模拟高原环境下大脑皮质及血脑屏障的病理变化与AQP4的相关性实验研究
4.6 低氧应激肽结构分析及与高原病相关性研究
4.7 缺血/低氧预适应研究
4.8 低氧暴露对细胞内感受器的影响
4.9 健康青年急进高原后凝血纤溶系统变化的研究

5 高原缺氧与氧自由基
5.1 自由基和OFR概况
5.1.1 自由基
5.1.2 氧化应激与OFR
5.2 OFR的损伤机制
5.2.1 生物膜的损伤
5.2.2 蛋白质的损伤
5.2.3 DNA和线粒体的损伤
5.2.4 细胞信号系统紊乱
5.2.5 细胞凋亡
5.3 OFR清除剂
5.3.1 酶类
5.3.2 维生素类
5.3.3 微量元素类
5.3.4 多肽类
5.3.5 中药
5.3.6 藏药
5.4 高原缺氧与OFR的关系
5.4.1 高原环境中OFR增多的可能机制
5.4.2 细胞凋亡可能是引起高原病的最终环节
5.4.3 OFR增多引起高原病的可能机制
5.5 防治
5.6 展望
……
6 高原缺氧对基因表达和基因调控的影响及其分子机制
7 高原缺氧与衰老
8 高原缺氧与细胞凋亡
9 高原缺氧与运动医学
10 高原病分子药理学
参考文献

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Brand Jingdong book
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